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Kamagra Oral Jelly Buy Online: Kamagra 50mg 4 tablets to buy in Bishkek, price in an online pharmacy 186.000000 som instructions for use, reviews, description, composition. Kamagra 50mg 4 tablets, home delivery around the clock

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Trade name Kamagra International nonproprietary name Sildenafil Dosage form Film-coated tablets 50 and 100 mg Ingredients One tablet contains the active substancesildenafil citrate 70 250/140 500 mg equivalent to sildenafil 50/100 mg auxiliary

active ingredient – sildenafil citrate 70,250 / 140,500 mg equivalent

Sildenafil 50/100 mg

Perform KamagraDeal

excipients kamagra effervescent: sodium starch glycolate (type A), povidone (PVPK 30), microcrystalline cellulose, purified talc, magnesium stearate,

shell: hypromellose, Instacoat Sol does kamagra work IC-S-3788 (green) 1, titanium dioxide (E 171)

1 – The composition includes: hypromellose (USP *), polyethylene glycol (NFSHA *), talc (USP *), brilliant blue E 133 (USP *), quinoline yellow E 104 (USP *), titanium dioxide E 171 (USP) *

Description

Tablets are green, diamond-shaped, film-coated, engraved with “ap” on one side and “KGR 50” on the other, from 11.4 to 11.6 mm long, 8.3 to 8.5 mm wide (for 50 mg dosage).

Tablets are green, diamond-shaped, film-coated, engraved with “ap” on one side and “KGR 100” on the other, 14.2 to 14.4 mm long, 10.2 to 10.4 mm wide (for a dosage of 100 mg).

Pharmacotherapeutic group

Drugs for the treatment of erectile dysfunction.

ATX code G04BE03

Pharmacological properties

Pharmacokinetics

sildenafil is dose dependent. After taking the drug inside, sildenafil is quickly absorbed by the kamagra 100mg oral jelly review. Absolute bioavailability, on average, is 41%. After taking the drug on an empty stomach Cmax is achieved within 30 minutes. When taking sildenafil in combination with fatty foods, the absorption rate decreases; Tmax increases by 60 minutes, and Cmax decreases on average by 29%. 96% Sildenafil is bound to plasma proteins. Protein binding does not depend on the total concentration of sildenafil. Sildenafil is metabolized in the liver. The major circulating metabolite is metabolized further. According to the selectivity of action, the metabolite is comparable to sildenafil, and its in vitro activity is about 50% of the activity of sildenafil itself. The concentration of the metabolite in plasma is approximately 40% of the concentration of sildenafil. Terminal T1 \ 2 is about 4 hours.

After ingestion or administration of intravenous administration, sildenafil is excreted as metabolites, mainly with feces (approximately 80%) and to a lesser extent with urine (approximately 13%).

Pharmacodynamics

Kamagra is a drug for the treatment of erectile dysfunction. Sildenafil citrate is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

Nitric oxide activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate (cGMP), relaxation of the smooth muscles of the cavernous body, and increased blood flow in the penis. When sexually aroused, the local release of NO under the influence of sildenafil leads to the inhibition of PDE5 and an increase in the level of cGMP in the cavernous body, as a result of which kamagra now relaxes smooth muscles and increases blood flow in the cavernous body. The use of sildenafil in the recommended doses is ineffective in the absence of sexual stimulation.

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Kamagra does not affect visual acuity, sensitivity to contrast, intraocular pressure, or pupil diameter.

The drug in a dose of 100 mg does not affect the locomotor activity or morphology of spermatozoa when it is taken once.

Toxicological characteristics of the drug

The drug belongs to virtually non-toxic substances. Does not have irritant effects. It has no teratogenic and embryotoxic action, does not possess immunotoxic and sensitizing action.

Indications for use

treatment of erectile dysfunction in men

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Dosage and administration

The drug is taken who makes kamagra inside; swallowing the pill whole and drinking a small amount of water. When taken on an empty stomach, the effect is faster. The drug is taken about 1 hour before sexual activity.

Apply strictly under medical supervision.

For most patients, the recommended order of kamagra online australia is 50 mg.

Taking into account the effectiveness and tolerability of the maximum single dose can be increased to 100 mg or reduced to 25 mg.

The drug is taken no more than once a day.

Any changes in the dosage of the drug should be done only on the recommendation of the attending physician.

Side effects

Often

– headache, migraine

Often

– dizziness

– visual impairment (moderate and short-term, mainly

expressed in violation of color perception, as well as increased

sensitivity to light or “blurred” vision)

– “flushed face

– nasal congestion, flu-like syndrome

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– dyspepsia

Infrequently

– mydriasis, conjunctivitis, photophobia, eye pain, hemorrhages ajanta kamagra in the eyes,

cataract

– tinnitus, pain in the ears

– shortness of breath, cough, laryngitis, pharyngitis, sinusitis, bronchitis, asthma

bronchial

– heartbeat, tachycardia, syncope, low blood pressure,

postural hypotension, peripheral edema, ischemia

myocardium, cerebral thrombosis, delay the next

heartbeat, heart failure, abnormalities

electrocardiogram, atrioventricular block, angina pectoris,

cardiomyopathy

– dry mouth, thirst, vomiting, stomatitis, gingivitis, glossitis, dysphagia,

esophagitis, gastritis, gastroenteritis, colitis, rectal bleeding

– chest pain, general weakness

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– lower back pain

– gout

– arthralgia, myalgia, tendon rupture, tendovaginitis, myasthenia gravis, synovitis,

arthritis, arthrosis

– ataxia, neuralgia, neuropathy, paresthesia, tremors, depression,

drowsiness, insomnia, insomnia, reduced reflexes, hypoesthesia

– urticaria, herpes simplex, skin rash, itching, increased

sweating, skin ulcers, contact dermatitis

– cystitis, nocturia, frequent urination, urinary incontinence

– swelling of dairy kamagra oral jelly walmart glands, impaired ejaculation, swelling of the genitals and

anorgasmia

– anemia, leukopenia

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– hyperglycemia, hypoglycemia, hyperuricemia, hypernatremia

Seldom

– cerebrovascular disorders, fainting

– deafness

– myocardial infarction, atrial fibrillation

– arterial hypertension

– nose bleed

Contraindications

hypersensitivity to any component of the drug

– simultaneous use of drugs that are nitric oxide donors,

organic nitrates or nitrites in any form

– heart failure

– unstable angina, infarction in the last 6 months

myocardium, stroke, or life-threatening arrhythmias

– arterial hypertension (blood pressure (BP)> 170/100 mmHg)

or hypotension (BP) < 90/50 мм рт ст)

– established congenital degenerative diseases of the retina

(retinitis pigmentosa, congenital defect of retinal phosphodiesterase)

– children and adolescents up to 18 years

– not intended for use in women

Drug interactions

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Effect of kamagra fast other drugs on Kamagra

Sildenafil metabolism is predominantly caused by cytochrome P450 (CYP), isoforms 3A4 (main metabolic pathway) and 2C9 (secondary metabolic pathway). Consequently, inhibitors of these isoenzymes can affect the clearance of sildenafil.

Cimetidine (800 mg), a non-specific CYP inhibitor causes a 56% increase in plasma concentration of the drug while taking it with sildenafil (50 mg) in healthy volunteers.

More potent CYP3A4 inhibitors, such as ketoconazole, itraconazole or mibefradil, are thought to have a stronger effect on taking kamagra on holiday. Data from clinical studies have shown a decrease in the clearance of sildenafil in patients while taking it with CYP3A4 inhibitors. It should be expected that the simultaneous intake of CYP3A4 inducers, such as rifampicin, may reduce the plasma concentration of sildenafil.

A single antacid (magnesium hydroxide / aluminum hydroxide) does not affect the bioavailability of sildenafil.

Pharmacokinetic data of patients in clinical studies did not show the effect of CYP2C9 inhibitors (such as butamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors and calcium channel blockers on the pharmacokinetic. The AUC of the active metabolite, N-desmethylsildenafil, increases by 62% under the influence of loop diuretics and potassium-saving diuretics, and by 102% when taken with non-specific beta-blockers. Such effects on the metabolite are not expected to have clinical consequences.

The effect of the drug on other drugs

In in vitro studies: the drug is a weak inhibitor of cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1, and 3A4 (IC50> 150 mM). At maximum plasma concentrations of the drug, which are approximately 1 mM after administration in recommended doses, it is unlikely that the drug will affect the clearance of the substrates of these isoenzymes.

In in vivo studies, buy kamagra oral jelly uk: no significant interactions were found when taken simultaneously with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9.

Kamagra (50 mg) does not affect the increase in bleeding time caused by aspirin (150 mg).

Kamagra (50 mg) does not enhance the hypotensive effect of alcohol in healthy volunteers with an average maximum blood alcohol level of 0.08%.

When the drug (100 mg) is taken simultaneously with amlodipine in hypertensive patients, the additional decrease in blood pressure in the supine position kamagra chewables (on average, systolic at 8 mmHg; diastolic – at 7 mmHg) has a similar magnitude observed when taking only one drug in healthy volunteers.

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Analysis of safety data showed no differences in the incidence of side effects in patients taking only Kamagra, and patients taking the drug with antihypertensives.

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special instructions

It is necessary to study the history of the disease and conduct a physical examination to diagnose erectile dysfunction, identify potential underlying causes and prescribe the appropriate treatment. To some extent, there is a risk of the cardiovascular system associated with sexual activity; Therefore, it is necessary for the physician to assess the state of the cardiovascular system of patients before prescribing any drugs for the treatment of erectile dysfunction.

Preparations for the treatment of erectile kamagra 100 chewable dysfunction should be administered with caution to patients with anatomical deformation of the penis (angular curvature, cavernous fibrosis or fibroplastic induration of the penis (Peyronie’s disease), or patients with concomitant diseases that can cause priapism (such as sickle cell anatomy) multiple myeloma or leukemia).

The safety and efficacy of the drug in combination with other drugs for the treatment of erectile dysfunction have not been studied. Therefore, the use of the drug in combination with such drugs is not recommended.

Kamagra does not affect the bleeding time as when taking the drug separately, and together with aspirin. Human platelets have shown that the drug enhances the antiplatelet effect of sodium nitrocyanide (a nitric oxide donor). Data on the safety of the drug in patients with impaired bleeding or the active form of peptic ulcers is not presented. Therefore, the drug should be prescribed with caution in such patients.

Some patients with hereditary retinal pigment degeneration have observed genetic disorders of retinal phosphodiesterase. There are no data on the safety of Kamagra in patients with retinal pigment degeneration. Consequently, the drug should be prescribed kamagra wiki with caution in such patients.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous machinery

Given the side effects of the drug, care should be taken when driving vehicles or other potentially dangerous machinery.

Overdose

When taking high doses of the drug may be increased side effects observed when taking the recommended doses. In case of overdose, general symptomatic and supportive treatment is prescribed.

Release form and packaging

On 4 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil lacquered printed.

On 1 planimetric package together with the instruction for medical application put in a pack from a cardboard.

Storage conditions

Store in a dark place at a temperature not exceeding 30 ° C.

Keep out of the reach of children!

Shelf life

3 years.

Do not use kamagra pill after the expiration date!

Pharmacy sales terms

On prescription

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