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Pharmacology power.

Pharmacodynamic.

Sildenafil is a preparation for oral zastosovannya, prigazenim for lіkuvannya rektilno ї dysfuntsії. In case of a state-of-the-art drug, vdovlyuyu kamagra for sale znizhenu erektilnu funktsiyu with the use of force flow to the penis.

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Physiological mecha- nism, which is reasonable for energy, including where I can get nitrogen (NO) in cavernous sands at an hour of state water. Vivіlneny nitrogen oxide aktivuє enzyme guanіlattsiklazu scho stimulyuє pіdvischennya rіvnya tsiklіchnogo guanosine monophosphate (cGMP) scho, at its Cherga, sprichinyaє rozslablennya gladenkoї musculature of cavernous til, spriyayuchi inflow krovі.

Sildenafil уж by the ta and selective іngіbіtorom cGMP-specific фосф phosphod_esterazi

5 (FDE5) in cavernous tillage, de FDE5 cheap generic viagra co uk kamagra oral jelly 100mg per_dovіdaє for rozpad cGMP. Efecti sildenafilu on erektsiyu be peripheral in nature. Sildenafil is not a cause without a second relaxation day on the cauliflower cavernosum of people, and I feel no need to relax the fabric of NO. With the active metabolism of NO / cGMP, to join the state of stimulation, sildenafil FDE5, with stimuli, stimulate cGMP in cavernous tilas. Thus, in order for sildenafil to be necessary pharmacological effect, it is necessary to wake up.

An in vitro report showed selectivity to Sildenafil on FDE5, because the active part of the erection process is active. The effect of sildenafil on FDE5 is weaker, and the effect is on іnshі vіdomі phosphodіesterazi. Tsei effect at 10 times the need, the effect on FDE6, so the fate of tania kamagra in the process of photo transformation in the city. When zastosuvannі maximum recommended doses of selectivity to sildenafil to FDE5, 80 times peristically selective selectivity to FDE1,

700 eriacta or kamagra razіv vishchi, nіzh to FDE2, FDE3, FDE4, FDE7, FDE8, FDE9, FDE10 and FDE11. Zokrem, selenilist sildenafilu to FDE5 at 4000 razіv peredivit yogogo selektivnіst up to FDE3 – cGMP-specific іzoforii phosphodіesterazi, sc utografii u regularia sertsevoy skorotlivost_.

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Pharmacokinetics.

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Absorption. Sildenafil quickly absorbed. The maximum plasma concentration of the drug is achieved by a strain of 30-120 minutes (from a median of 60 minutes) after the first oral administration. The middle is absolute bioavailability of the oral dose of kamagra 100 oral jelly 41% (with a range of 25% to 63%). At the recommended dose range (25–100 mg), the concentration-per-hour curve (AUC) shows the maximum concentration (Cmax) of sildenafil per hour of oral peroral concentration at a proportion of dosage.

When zasosuvannі sildenafilu pіd hour, I take іжі step of absorption to decrease from middle podmozhennyam Tmax up to 60 khvilin і middle middle of lowered Cmax on 29%.

Rospodil The middle revival of both rosopodlis (Vd) is 105 liters, and you can tell about the dosage of the drug in organisms in tissues and tissues. When administered as a single oral dose, sildenafil at a dose of 100 mg of the mean is the maximum zonal plasma concentration for sildenafil to be approximately what is kamagra oral jelly 440 ng / ml (40% nfcc). Oskilka zyazyuvannya sildenafilu yogo head N-desmethyl-metabolite with plasma of reach of 96%, mean maximum plasma concentration of sildenafil reachy 18 ng / ml (38 nmol). Stupin sv’yazuvannya with bilkami plasma blood not to lie outside of the main concentration sildenafilu.

In healthy volunteers, Yakі zastosovuvali sildenafіl one time at a dose of 100 mg, after 90 hours in the ejaculate were less than 0.0002 kamagra jelly 100mg% (in the middle 188 ng) vod stagnated doz.

Biotransformatsiya. Metabolism of sildenafile is associated with a headache for the participation of microsomal isofermentists of CYP3A4 (head) and CYP2C9 (head).

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Head circulatory metabolism is established by the gate N-demetilyuvannya sildenafilu.

The selectivity of the metabolism is FDE5 porous, kamagra chewable with selectivity of sildenafil, and the activity of the metabolism of FDE5 is approximately 50% ad hoc activity. Plasma concentrations of the metabolite become approximately 40% of the concentration of sildenafil in plasma of blood. N-demethylation of the metabolism of the subordinate to the metabolism, and the period of his stupa to become approximately kamagra oral jelly what is it 4 years.

Elimina. Zalniy klyrens sildenafilu 41 l / year, zumovlyuyuchi per iod yogo napivivivedennya trivalіstyu 3-5 years. Yak pіslya oral, so і pіslya vnutrіshnёvennogo zaosuvannya екkrekіya sildenafіlu in viglyadі mebіnіtіv to look like a golovny ı ız feces (approximately 80% of the orally administered dosage), and I will get a class I-you will need a $ 100, and I will get an order set.

Patsі вnti lіtnogo vіku. In the case of the volunteer 18-45 rokiv). The linkage with each other’s attitudes to the plasmablashes of the blood plasma of the population concentration of approximately 40% became the plasma concentration of sildenafil.

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Nirkova lack of. In volunteers, in the form of pirushennye functions, nirok of the lung and the level of severity (klerens creatine from 30 to 80 ml / xb), the pharmacokinetics of sildenafil was filled with an unremarkable one-time single oral administration of dose 50. Middle AUC and Cmax N-demethylated metabolite

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